Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas
نویسندگان
چکیده
منابع مشابه
Identification of active regulatory regions from DNA methylation data
We have recently shown that transcription factor binding leads to defined reduction in DNA methylation, allowing for the identification of active regulatory regions from high-resolution methylomes. Here, we present MethylSeekR, a computational tool to accurately identify such footprints from bisulfite-sequencing data. Applying our method to a large number of published human methylomes, we demon...
متن کاملCpG methylation regulates the Igf2/H19 insulator
The differentially methylated 5'-flank of the mouse H19 gene unidirectionally regulates the communication between enhancer elements and gene promoters and presumably represses maternal Igf2 expression in vivo [1-6]. The specific activation of the paternally inherited Igf2 allele has been proposed to involve methylation-mediated inactivation of the H19 insulator function during male germline dev...
متن کاملCopy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors
Overexpression of insulin growth factor 2 (IGF2) is a hallmark of adrenocortical carcinomas and pheochromocytomas. Previous studies investigating the IGF2/H19 locus have mainly focused on a single molecular level such as genomic alterations or altered DNA methylation levels and the causal changes underlying IGF2 overexpression are still not fully established. In the current study, we analyzed 6...
متن کاملDNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament
BACKGROUND DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158). RESULTS MEG3 DMR levels were positively associated with internalizing (β = 0.15, P = 0.044) ...
متن کاملFamilial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions.
Loss of imprinting (LOI) has been observed in many types of human tumors and may be a predisposing event in some colon cancers. LOI is strongly associated with alteration of normal DNA methylation patterns in differentially methylated regions (DMRs) of affected loci but it is not known whether LOI is caused by stochastic, environmental or genetic factors. We have developed a simple, quantitativ...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2016
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-16-0266